Internal validity of trials is more important than generalisability

Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...

Imagination is more important than knowledge.

A Imagination is more important than knowledge

Ongoing acute endovascular stroke trials: is execution more important than design?

W ith the failure of multiple recent acute stroke trials to show the benefit of endovascular treatment, there has been a lot written and spoken about next steps. In the wake of these results, many new trials have started with slightly varying principles, selection criteria, and depending on their sponsor, different devices. All these trials have tried to overcome the design limitations of the p...

Analysis of variance---why it is more important than ever

Analysis of variance (Anova) is an extremely important method in exploratory and confirmatory data analysis. Unfortunately, in complex problems (for example, splitplot designs), it is not always easy to set up an appropriate Anova. We propose a hierarchical analysis that automatically gives the correct Anova comparisons even in complex scenarios. The inferences for all means and variances are p...